UNOS data scientists explore organ donor admission text to help understand and predict how kidney acceptance decisions are made.
Natural language processing models applied to deceased organ donor admission text may offer additional insights into kidney discard behavior.
Approximately 13 end-stage renal disease patients die each day awaiting an organ transplant in the U.S., according to data from the Organ Procurement and Transplantation Network, while 20 percent of kidneys recovered from deceased donors are not transplanted.
“The potential to improve existing kidney utilization prediction models is limited if further attempts are based solely on the same traditional OPTN data sources,” said United Network for Organ Sharing data science manager Andrew Placona. “Often the only way to improve model performance is by incorporating new data sources or finding new insights within the data.”
Placona is corresponding author in a new proof-of-concept article published in the American Journal of Transplantation that explores the possibility of using natural language processing to mine the free-text fields of deceased organ donor registration forms for information that might predict kidney utilization rates. Existing predictive algorithms have only leveraged structured data, such as yes or no questions, which may not provide sufficient detail to enable fully informed organ offer acceptance.
“We’re using data that traditionally UNOS has never touched,” Placona said. “No one has really looked at the clinical text yet and it’s gone unnoticed for decades because it is not easy data to work with.”
Placona, A., Martinez, C., McGehee, H., Carrico, B., Klassen, D.K. and Stewart, D. (2019), Can Donor Narratives Yield Insights? A Natural Language Processing Proof of Concept to Facilitate Kidney Allocation. Am J Transplant. Accepted Author Manuscript. doi:10.1111/ajt.15705
Carlos Martinez and Andrew Placona were among more than two dozen UNOS researchers to present at the 2020 American Transplant Congress.
Research shows a link between a recipient’s age and a relative donor’s age in predicting end-stage renal disease (ESRD) post-donation.
Participating kidney programs performed an increased number of 51-100 percent KDPI transplants while maintaining one-year graft survival rates.