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Update: CPRA calculation

Update: CPRA calculation

Implementation date

Jan. 26, 2023


The new formula for Calculated Panel Reactive Antibody (CPRA) will now go into effect on Jan. 26, 2023. 

The revised CPRA calculation will more accurately reflect sensitization by:

  • Incorporating HLA-DQA1, DPB1, and DPA1 loci
  • Returning a CPRA value for allele-level antibodies
  • Using updated genotype frequencies based on a larger and newer dataset obtained from the National Marrow Donor Program (NMDP) donor registry

Candidates who do not have any unacceptable antigens reported will no longer reflect a 0% CPRA. The CPRA score for those patients will appear as blank, or NULL, in the system. It is still possible for candidates to have a 0% CPRA when reporting unacceptable antigens that result in a calculated value of 0%.

Additionally, CPRA will now be saved and available to view for all organ types. This will allow for future projects to incorporate CPRA into allocation for other organ groups if policy changes require and can aid members in understanding the sensitization of their patient population.

These changes are also being applied to the KPD application in UNetSM.

What you need to do

Upon implementation on Jan. 26, 2023, Transplant Hospital Programs can view which candidates still require documentation of written approval for CPRA greater than 98% by selecting Reports in Waitlist and then selecting ‘Kidney Candidate CPRA Greater than 98% Approvals Report’.

If a candidate has at any point had >98% approvals entered in Waitlist previously, those entries will fulfill the requirement with the new implementation as well.

Additional details

The OPTN site calculator will also be updated to reflect the new CPRA changes and will be released the same day, Jan. 26, 2023. At that time, the Legacy calculator will be removed from the OPTN site.

Education and resources

Existing UNOS Connect courses on CPRA will be updated with new information ahead of implementation.

A FAQ for patients about the coming changes is available on

If you have questions relating to implementation, contact UNOS Customer Service at [email protected], or call 800-978-4334 from 8 a.m. to 7 p.m. ET.

For policy-related questions, contact [email protected].

The Organ Center is available 24 hours a day at 800-292-9537.

View the UNetSM System Status page

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